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L-ASPARTIC ACID B-TERT-BUTYL ESTER

H-Asp(OtBu)-OH

CAS: 3057-74-7

Molecular Formula: C8H15NO4

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L-ASPARTIC ACID B-TERT-BUTYL ESTER - Names and Identifiers

Name H-Asp(OtBu)-OH
Synonyms H-ASP(OTBU)-OH
H-ASP(OBUT)-OH
H-Asp(OtBu)-OH
ASPARTIC ACID(OTBU)
L-ASPARTIC ACID B-TERT-BUTYL ESTER
L-ASPARTIC ACID BETA-T-BUTYL ESTER
L-Aspartic acid-4-tert-butyl ester
L-ASPARTIC ACID 4-TERT-BUTYL ESTER
L-Aspartic acid 4-tert-butyl ester
(2S)-2-ammonio-4-tert-butoxy-4-oxobutanoate
(2R)-2-ammonio-4-tert-butoxy-4-oxobutanoate
ASPARTIC ACID BETA T-BUTYL ESTER MONOHYDRATE
L-ASPARTIC ACID BETA-T-BUTYL ESTER MONOHYDRATE
2-amino-4-tert-butoxy-4-oxobutanoic acid (non-preferred name)
CAS 3057-74-7
EINECS 221-292-8
InChI InChI=1/C8H15NO4/c1-8(2,3)13-6(10)4-5(9)7(11)12/h5H,4,9H2,1-3H3,(H,11,12)/t5-/m1/s1

L-ASPARTIC ACID B-TERT-BUTYL ESTER - Physico-chemical Properties

Molecular FormulaC8H15NO4
Molar Mass189.21
Density1.162±0.06 g/cm3(Predicted)
Melting Point220°C (dec.)
Boling Point318.7±37.0 °C(Predicted)
Flash Point146.5°C
Solubility Methanol (Slightly), Water (Slightly, Sonicated)
Vapor Presure7.48E-05mmHg at 25°C
AppearanceSolid
ColorWhite to Off-White
BRN4671089
pKa2.19±0.23(Predicted)
Storage ConditionKeep in dark place,Inert atmosphere,Room temperature
StabilityHygroscopic
Refractive Index1.475
MDLMFCD00038577

L-ASPARTIC ACID B-TERT-BUTYL ESTER - Risk and Safety

Risk Codes36/37/38 - Irritating to eyes, respiratory system and skin.
Safety DescriptionS22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S44 -
S35 - This material and its container must be disposed of in a safe way.
S28 - After contact with skin, wash immediately with plenty of soap-suds.
S7 - Keep container tightly closed.
S4 - Keep away from living quarters.
WGK Germany3
HS Code29225090

L-ASPARTIC ACID B-TERT-BUTYL ESTER - Reference Information

Application L-aspartate-4-tert-butyl ester is abbreviated as Asp(OtBu), which can be prepared by the reaction of aspartic acid and isobutylene. It has been reported that it can be used to prepare (Asp)8-ODN conjugates.
preparation 1000mL of dichloromethane was added into a 3000mL three-mouth bottle, the temperature was reduced to -5 ℃, 344g of anhydrous p-toluenesulfonic acid and 133g of aspartic acid was added, 448g of isobutylene was introduced, and the reaction was maintained at -5 ℃ for 50 hours. Then adjust the pH to 7 with 10% Na2CO3 aqueous solution, separate the solution, wait for use in the aqueous layer, evaporate under, A mixture of Asp(OtBu)2,
Asp(OtBu) and Asp-OtBu oil was prepared, and the oil was combined with the water layer for later use with a yield of 58.4%. The obtained mixture was transferred into a 3000mL three-mouth bottle, 125 gCuSO4 · 5H2O was added,
pH was adjusted to 3 with concentrated hydrochloric acid, stirred and heated to 40 ℃, and reacted for 16 hours to prepare Cu[Asp(OtBu)]x(x = 1~2); When it is reduced to room temperature, 186.3g
Na2EDTA · 2H2O and 400mL dioxane are added, and the pH is adjusted to 8~9 with triethylamine, L-aspartate -4-tert-butyl ester was prepared.
Last Update：2024-04-09 20:52:54
L-ASPARTIC ACID B-TERT-BUTYL ESTER
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Shanghai Yuanye Bio-Technology Co., Ltd.
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CAS: 3057-74-7
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Shanghai Yuanye Bio-Technology Co., Ltd.
Product Name: L-Aspartic acid 4-tert-butyl ester Visit Supplier Webpage Request for quotation
CAS: 3057-74-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Sichuan Hengkang Science and Technology Development Co.,Ltd.
Product Name: H-Asp(OtBu)-OH Request for quotation
CAS: 3057-74-7
Tel: +86-18980427282
Email: hk999@hengkangtech.com
Mobile: +86-18980427282
QQ: 1525088774 Click to send a QQ message
Wechat: 18980427282
WhatsApp: 15008222507
Linkedin: linkedin.com/in/teresa-li-806a0095
Product List: View Catalog
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L-ASPARTIC ACID B-TERT-BUTYL ESTER
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